Serum manufacturing · Hauppauge, New York
Serum Manufacturing for Skin Care Brands
Private label serums from a catalogue of more than 300 formulas, or full custom serum contract manufacturing from a blank page. Made in one NSF GMP, FDA-registered New York facility, with the botanical extracts produced on the same site.
- Published minimum: 5,000 units on standard serum fills
- We extract our own botanicals — the actives are not a third-party purchase
- Water-thin gel, light emulsified, oil-phase and biphasic serums
- NSF GMP · FDA-registered facility · USDA Organic · Kosher · Halal
Talk to a formulator: (631) 231-5522
Get a quote on your serum
Tell us the serum you have in mind. A formulator reviews every request — not a call centre.
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No obligation. We reply the same business day. Ask for samples in the box above and we will tell you what we can send.
NSF GMP
FDA-registered facility
USDA Organic
Kosher
Halal
Made in Hauppauge, NY
Extracting botanicals since 1972
1972
Extracting botanicals since
160,000 sq ft
FDA-registered New York facility
5,000 units
Minimum on standard serum fills
300+
Private label formulas ready now
What kinds of serums can you manufacture?
BioB Manufacturing makes water-thin gel serums, light emulsified serums, oil-phase and biphasic serums, and botanical-extract-forward serums, filled into glass dropper bottles, airless pumps and treatment bottles. The formula can come from our catalogue of more than 300 private label bases, from a modified base, or from ground-up custom development.
Water-thin gel serums
A single water phase thickened with a gum or synthetic gelling polymer. No oil phase, no emulsifier — the clearest serums, and the format best suited to a glass dropper.
Light emulsified serums
A small oil phase carried in water with an emulsifier, giving a milky or translucent fluid. The route when a formula must carry oil-soluble material and still feel weightless.
Oil-phase and biphasic serums
Anhydrous facial oils, and two-phase serums that separate in the bottle and are shaken before use. Biphasic fills need a pack that shows the split cleanly and holds the ratio.
Botanical-extract-forward serums
Serums built around botanical extracts rather than one synthetic active. We extract botanicals ourselves, so the specified material and the material in the tank share one origin.
How is a serum manufactured?
A serum is made by preparing its phases separately, combining them under controlled mixing, adjusting the bulk to specification, filtering it, and filling it into its primary pack. A water-thin gel serum skips the emulsification step; an emulsified serum requires it. Every stage is recorded against a batch record.
- Phase preparation. The water phase — purified water, humectants, water-soluble botanical extracts, chelating and pH-adjusting materials — is prepared. Any oil phase is prepared separately with its emulsifier.
- Gelling or emulsification. A gel serum has its polymer dispersed and hydrated until the network is fully developed and free of fisheyes. An emulsified serum has the oil phase added under high-shear homogenisation.
- Cool-down additions. Heat-sensitive material — many botanical extracts, fragrance, the preservative system — goes in during cool-down rather than at the hot stage.
- In-process checks. Appearance, pH and viscosity are checked against the agreed specification and adjusted within the limits it allows, before the bulk is cleared for filling.
- Filtration. The bulk is filtered to remove undispersed material and handling debris. Clear gels are least forgiving here: a particle that vanishes in a cream is visible in a dropper.
- Filling. The bulk is filled into glass dropper bottles, airless pumps or treatment bottles, then capped, sealed, labelled and cased, with fill weight checked through the run.
Which actives can a serum carry, and at what level?
That is a formulation conversation, not a catalogue answer. Whether an active works in a serum, at what percentage and at what pH, depends on the system it goes into: the solvent, what competes for the same solubility, and how the pack behaves. We will tell you what looks workable in your system and what we would want to test first. What we will not do is promise to hold any named active at any named level, because that answer differs in every formula.
What is the minimum order quantity for serum manufacturing?
The minimum order quantity for a serum is 5,000 units. Serum fills are almost always under 8 oz, so 5,000 units applies to essentially every serum programme, whatever the pack. Topical liquids filled at 8 oz and above run at a 2,500-unit minimum. These numbers are published, not held back for a call.
| Serum format and pack | Typical fill | Minimum order | Lead time |
|---|---|---|---|
| Gel or emulsified serum, glass dropper bottle | 0.5 – 2 oz | 5,000 units | Confirmed at quote — set by packaging |
| Serum in an airless pump | 1 – 2 oz | 5,000 units | Confirmed at quote — set by packaging |
| Serum or essence, treatment bottle with pump or fine mist | 2 – 4 oz | 5,000 units | Confirmed at quote — set by packaging |
| Oil-phase or biphasic serum, glass dropper bottle | 0.5 – 2 oz | 5,000 units | Confirmed at quote — set by packaging |
| Sample or trial-size serum | Under 8 oz | 5,000 units | Confirmed at quote |
| Topical liquid filled at 8 oz and above | 8 oz and up | 2,500 units | Confirmed at quote |
Fill sizes shown are the usual range for each pack; your exact fill, components and schedule are confirmed at quote. We publish no generic turnaround because the honest answer is set by your packaging, not by filling capacity. Minimums for formats not listed here are confirmed at quote, not guessed at.
Private label, semi-custom or full custom serum?
Three routes. Private label puts your brand on one of more than 300 existing formulas. Semi-custom starts from one of those bases and changes the actives, the botanical, the viscosity or the scent. Full custom develops a serum from a blank page. Semi-custom is the most common start, because a proven base removes most of the formulation risk.
Private label serum
You choose from the catalogue and we fill it under your brand. Fastest route, lowest development effort, formula already made and documented. Best when the differentiation lives in the brand, not the chemistry.
Semi-custom serum
We start from a proven base and change what matters — swap or add a botanical extract, move the actives, adjust viscosity and slip, change or drop the fragrance. Yours, without a ground-up development cycle.
Full custom serum
Ground-up contract manufacturing with our formulators, worked from a brief, a benchmark or a texture you want to hit. The longest route, the most sampling, and the only one nobody else can buy.
Where do the botanical actives in your serums come from?
We make them. Bio-Botanica has extracted botanicals since 1972, and BioB Manufacturing is the finished-goods arm of that business. When a serum in our catalogue calls for a botanical extract, that extract is produced in the same Hauppauge facility that fills the bottle.
That matters more in a serum than in almost any other format. A serum is a thin, often clear system where the extract is much of what the buyer is paying for, and any change to it shows immediately in colour, odour and clarity. Buying on the open market means a change of supplier is a change of material — and in a clear serum, that is something your customer can see. Topical serums use glycerin-based botanical extracts, not the alcohol-free extracts used on the ingestible side.
No manufacturer currently ranking on page one for serum manufacturing controls its own extract supply. See our standards and certifications for how that supply is qualified and documented.
What happens between your first email and your first pallet?
Six steps: scoping, formula selection or development, sampling, packaging selection, documentation and specification sign-off, then production and release. Each stage produces something you can review before the next begins, and nothing reaches a filling line until you have approved both the sample and the specification in writing.
1
Scope the project
A formulator, not a salesperson, establishes what you are making: format, fill, pack, target texture, the actives you want on the label, and whether the product is a cosmetic or an OTC drug.
2
Choose or develop the formula
We pull a catalogue base, modify one, or open a custom development. This is where we tell you plainly which parts of the brief are straightforward and which will take work.
3
Sample and iterate
You assess texture, colour, odour, slip and how the serum behaves in your intended pack. Iteration is normal; rounds are scoped with the project rather than assumed to be one.
4
Lock the packaging
Glass dropper, airless pump or treatment bottle. Components drive a serum schedule more than anything else, so they are settled early and compatibility confirmed with your actual formula.
5
Sign off the specification
Finished-goods specification, ingredient declaration in INCI order, artwork check and quality agreement, all in writing before a batch is scheduled. The testing plan is fixed here too.
6
Produce, document, release
The batch runs against a batch record in Hauppauge, is checked against the agreed specification, and ships with its documentation. Repeat orders run against the same record.
What testing and documentation comes with a serum batch?
Each batch is manufactured against a batch record in an NSF GMP, FDA-registered facility and released against the finished-goods specification agreed with you before production. You receive a Certificate of Analysis for the batch, the ingredient declaration in INCI order, and the manufacturing documentation set out in your quality agreement.
- A Certificate of Analysis for the batch, against the agreed specification — not a generic template.
- The finished-goods specification itself: appearance, pH, viscosity and the other attributes the formula is released on.
- The ingredient declaration in INCI order, in the form your labelling and your FDA listing need.
- Batch and lot traceability back through the manufacturing record.
- Confirmation of the facility's NSF GMP certification and its FDA facility registration.
- Retention samples and their retention period, where set out in the quality agreement.
Which tests run, and who runs them, is decided at scoping and written into the specification rather than left implied. Microbial testing, challenge testing of the preservative system, stability and compatibility work in the actual pack, and any testing needed to support a claim are scoped per formula. The quote says which sit inside the programme, which are quoted separately, and which go to a third-party lab.
Who is responsible for MoCRA compliance on a serum?
Responsibility is split. Under the Modernization of Cosmetics Regulation Act the manufacturer registers and biennially renews the facility with FDA. The brand is normally the Responsible Person: the party that lists the product with FDA, whose name appears on the label, and that holds the safety substantiation records for the finished serum.
| MoCRA obligation | Who normally holds it |
|---|---|
| Facility registration and biennial renewal | The manufacturer. BioB registers and maintains the Hauppauge facility. |
| Good manufacturing practice at the site | The manufacturer. |
| Batch records, finished-goods specification and the batch COA | The manufacturer. |
| Cosmetic product listing with FDA | The brand, as Responsible Person. |
| Responsible Person name and contact on the label | The brand, as Responsible Person. |
| Adequate substantiation of safety for the finished product | The brand, as Responsible Person, built from formulation, ingredient and testing information. |
| Serious adverse event reporting and the associated records | The brand, as Responsible Person. |
We supply the manufacturing-side information a Responsible Person needs for that file — formula and ingredient information, the specification, the batch documentation — but the listing, the label and the safety substantiation file are the brand's to hold. FDA sets this out on its page covering registration and listing of cosmetic product facilities and products.
One more thing to raise at scoping. A serum is only a cosmetic if it is sold as one. A serum marketed as a sunscreen, or as an acne treatment, is an over-the-counter drug product in the United States and sits under the OTC monograph system, not under MoCRA. That changes the label, the testing and the whole regulatory pathway, so say so on the first call.
Why brands choose BioB for serum manufacturing
We make the actives
Botanical extraction since 1972, on the site that fills your bottles. The extract in your specification is not a purchase order to somebody else's factory.
One US site
One 160,000 sq ft facility in Hauppauge, New York. No ocean freight inside your launch date, no tariff surprise in your landed cost, no time-zone gap on a batch question.
Published minimums
5,000 units on standard serum fills, in writing, on this page. Several manufacturers ranking for this term promise a low minimum in the page title, then publish no number at all.
Ingestible and topical under one roof
A serum plus a companion supplement needs one vendor, one quality system, one documentation package. We make liquids, capsules, tablets and powders alongside creams, serums, lotions and sprays.
We tell you what you are liable for
The MoCRA split above is published here because you should know it before signing a supply agreement, not after your first listing deadline.
Formulators, not a call centre
The person who reads your enquiry is the person who can say whether the brief is workable. You get a straight answer about the hard parts early, when it is still cheap.
Serum manufacturing FAQ
What is the minimum order quantity for serum manufacturing?
5,000 units. Serum fills are essentially all under 8 oz, so 5,000 units applies to virtually every serum programme, whatever the pack. Topical liquids filled at 8 oz and above run at a 2,500-unit minimum. Those numbers are published here rather than held back for a call.
How is a serum manufactured?
The phases are prepared separately, then combined under controlled mixing: high-shear homogenisation for an emulsion, full polymer hydration for a gel. Heat-sensitive material including botanical extracts and the preservative system is added at cool-down. The bulk is checked against specification, filtered, then filled into droppers, airless pumps or treatment bottles.
What is the difference between a gel serum and an emulsified serum?
A gel serum is a single water phase thickened with a gelling polymer: clear, light, no oil and no emulsifier. An emulsified serum carries a small oil phase in water with an emulsifier, so it looks milky or translucent and can carry oil-soluble material.
Should I choose a private label serum or a custom serum?
Private label if you need a credible serum in the line quickly and the differentiation is in your brand. Full custom if the formula itself is the product. Semi-custom sits between: start from a proven base, change the actives, botanical, viscosity or scent, and skip most of a development cycle.
What packaging can you fill serums into, and how is compatibility confirmed?
Glass dropper bottles, airless pumps, and treatment bottles with a pump or fine mist are the common serum packs. Compatibility is confirmed with your actual formula in your actual component rather than assumed from the pack type, because a clear gel in clear glass shows every issue a cream would hide.
Who is the Responsible Person for a serum under MoCRA?
Normally the brand. Under MoCRA the manufacturer registers and biennially renews the facility, while the Responsible Person named on the label lists the product with FDA and maintains the safety substantiation records. For a private label or contract-manufactured serum, that Responsible Person is almost always the brand owner.
Do you provide a Certificate of Analysis and batch documentation?
Yes. Each batch is released against the finished-goods specification agreed before production and ships with a Certificate of Analysis for that batch, the ingredient declaration in INCI order, and lot traceability. Retention samples and their retention period are set out in the quality agreement.
Can I get samples before committing to production?
Yes. Physical samples are part of every route, whether the serum comes from the catalogue, a modified base or ground-up development. You assess texture, colour, odour, slip and behaviour in the intended pack before anything is scheduled. Iteration rounds are normal and are scoped with the project.
What sets the timeline on a serum project?
Packaging, usually. Filling capacity is rarely the constraint on a serum; the glass dropper, the pump or the decorated component is. The other movers are how many sampling rounds you need and how quickly the specification, artwork and quality agreement are signed off.
Where do the botanical actives in your serums come from?
From our own facility. Bio-Botanica has extracted botanicals in Hauppauge, New York since 1972, and BioB Manufacturing is its finished-goods arm. Topical serums use glycerin-based botanical extracts, so the material named in your specification and the material in the tank come from the same site.
What shelf life and period-after-opening should I expect on a serum?
Those are not numbers a manufacturer can hand you off a list. They follow from the formula, the preservative system, the pack and the testing that supports them. We agree a target at scoping, say what testing would be needed to support it, and state on the quote who performs it.
Do you make creams and lotions as well as serums?
Yes. Creams, lotions, sprays and oils run on the same 5,000-unit topical minimum, and we make ingestibles in the same facility: liquids, capsules, tablets and powders. A serum with a companion cream or supplement can stay with one manufacturer.
Get a quote on your serum programme
Tell us the serum you have in mind — a catalogue base under your brand, a modified version of one, or something that does not exist yet. A formulator reads it and replies the same business day. Published minimum: 5,000 units on standard serum fills.
Or call (631) 231-5522 · book a 30-minute call