Bio-Botanica, Inc. supplies an AF (alcohol-free) Dong Quai extract, a glycerin-carrier liquid engineered for ingestible supplement applications, for brands building in the women's health space.
The women's health supplement category is one of the clearest growth signals in nutraceuticals right now, and Dong Quai (Angelica sinensis) is a foundational ingredient in it.
Gen Z is the fastest-growing cohort in women's health supplementation. Per NutraIngredients (April 2025), 17% of Gen Z respondents use health apps to track their ovulation, nearly three times the rate of the general population, signaling active demand for products that align with hormonal health, menstrual cycles, and reproductive wellness.
This cohort doesn't see supplements as occasional fixes. Per champion-bio.com's 2025 Gen Z supplement report, women's health personalization, including cycle support, hormonal balance, and fertility-adjacent formulations, is described as being "in rapid ascent" among Gen Z buyers. They discover through TikTok and Instagram and make purchase decisions based on ingredient transparency and sourcing story. Dong Quai's deep TCM heritage, readable ingredient name, and traditional use profile* give it the authenticity signal this consumer rewards.
Holland & Barrett reported a 22% year-on-year uplift in women's health supplement sales in 2025 per NutraIngredients, spanning hormone support, fertility, and cycle-related categories. That lift is coming from younger demographics who are proactive, not reactive, about their health.
Dong Quai (Angelica sinensis) is a root herb from the Apiaceae family, cultivated primarily in the Gansu, Sichuan, and Shaanxi provinces of China. It carries one of the longest continuous use records in traditional Chinese medicine, over 2,000 years, as a traditional women's tonic.*
In supplement formulations, Dong Quai is a workhorse in the [women's health support](https://www.bio-botanica.com/product-category/function-supports/womens-health/) category. Brands commonly place it in liquid supplements, softgels, tinctures, capsule fills, and functional wellness shots targeting cycle support*, hormonal balance*, and overall vitality.* It also appears in multi-ingredient botanical blends alongside complementary TCM herbs.
Per NutraIngredients (January 2026), the broader botanical-based women's health segment saw significant activity through 2025, with traditional-use botanicals gaining traction as consumer trust in recognizable heritage ingredients grows. Dong Quai's traditional use profile* positions it well in that story.
Bio-Botanica manufactures [Dong Quai AF (alcohol-free) extract](https://www.bio-botanica.com/product/dong-quai-af/), a glycerin-carrier liquid extract engineered specifically for ingestible applications. This is the format for supplement manufacturers building liquid supplements, functional shots, tincture-style products, and capsule-fill systems.
Our AF line is food-grade, carries no alcohol, and is produced in our SQF-certified, cGMP-compliant, FDA-registered facility on Long Island. It integrates into aqueous supplement systems and supports clean-label ingredient listings, no alcohol to declare, no synthetic carriers.
The short answer: our Bio-Chelated® Cold Extraction Process. Developed by company founder Frank Senior, it operates on the principle that "life supports life", meaning very low or no heat is applied during extraction. That matters because heat is the primary cause of constituent degradation in botanical processing.
Our Bio-Chelated process uses traditional alcohol-based extraction methods, customized per plant, with extraction cycles running days to weeks depending on the botanical. The result is a Holistically Balanced® extract, one that reflects the plant's natural constituent ratios as it was grown, not a fraction of it. We don't isolate and standardize to a single compound. Our full-spectrum Dong Quai extract delivers the complete profile of the root.
For supplement brands competing on quality positioning, that distinction matters on a spec sheet and on a label.
**Extraction and Quality Comparison**
| Attribute | Bio-Botanica AF Dong Quai Extract | Typical Commodity Powder |
|---|---|---|
| Extraction method | Bio-Chelated® Cold Extraction | High-heat solvent extraction |
| Constituent profile | Full-spectrum (Holistically Balanced®) | Often fractionated |
| Format | Liquid AF (alcohol-free), glycerin carrier | Dried powder |
| Application fit | Liquid supplements, shots, tinctures, capsule fills | Capsules, tablets |
| Alcohol content | None | N/A |
| Facility certification | SQF (GFSI-recognized), cGMP, FDA-registered | Varies |
| Origin | American manufacturer, 53+ years | Varies |
| 3rd-party testing | Yes | Varies |
Our AF (alcohol-free) Dong Quai extract, a glycerin-carrier liquid formulated for ingestible applications, integrates into a wide range of supplement delivery systems.
Liquid supplements and tinctures are the natural primary fit, the format mirrors how Dong Quai has been delivered in traditional practice for centuries. Functional wellness shots (1, 2 oz formats) work well for brands building in the women's wellness shot space. Capsule fills and softgel systems also accept the liquid extract. Multi-ingredient botanical blends targeting cycle support* or hormonal balance* are a strong commercial opportunity, particularly as Gen Z's demand for targeted women's health formulations accelerates into 2026.
Drop format and glycerin base also mean no alcohol labeling requirement, which simplifies the label for brands positioning clean-label products.
Bio-Botanica, Inc. has maintained global botanical sourcing relationships for 53+ years. Our Dong Quai root is identity-tested and 3rd-party validated before it enters our extraction process. We source from our established network of botanical suppliers, with full chain-of-custody documentation.
Our facility holds SQF certification (a GFSI-recognized standard), making it one of the highest food-safety benchmarks available in the industry. Organic and Kosher options are available on applicable SKUs. Halal certification (American Halal Foundation) is also available. For supplement brands that need to check those compliance boxes, we've built the infrastructure.
Bio-Botanica, Inc. is a family-owned botanical extract supplier, specializing in liquid formulations, with 53+ years of extraction expertise. American-made. BBB Accredited. Fully integrated from sourcing through finished extract.
---
**What is Dong Quai (Angelica sinensis) traditionally used for in supplement formulations?**
Dong Quai is traditionally used in women's health supplement applications for cycle support, hormonal balance, and vitality.* It carries a 2,000+ year record of use in traditional Chinese medicine as a women's tonic* and is a foundational ingredient in the TCM-inspired botanical supplement space. It appears in liquid supplements, tinctures, functional shots, and multi-botanical blends targeting women's wellness.*
**What extract format does Bio-Botanica offer for Dong Quai?**
Bio-Botanica offers Dong Quai in the AF (alcohol-free) fluid extract format, a glycerin-carrier liquid engineered for ingestible supplement applications. This is designed for liquid supplements, functional shots, tincture-style products, and capsule fills. It is food-grade, carries no alcohol, and is produced in an SQF-certified, cGMP-compliant, FDA-registered facility.
**Does Bio-Botanica's Dong Quai extract work in aqueous-based supplement systems?**
Yes. Our AF (alcohol-free) Dong Quai extract, formulated as a glycerin-carrier liquid for ingestible applications, integrates into aqueous supplement systems. It carries no alcohol, which simplifies clean-label formulation. Work with our team on format selection based on your target system, viscosity, and pH requirements.
**What certifications does Bio-Botanica's Dong Quai extract carry?**
The extract is produced under cGMP and SQF (GFSI-recognized) certification in our FDA-registered, American-made facility. 3rd-party testing is standard. USDA Organic, Kosher (K-Parve), and Halal (American Halal Foundation) options are available on applicable SKUs. Identity testing and full sourcing documentation are included.
**How does Bio-Chelated® Cold Extraction differ from standard botanical extraction?**
Bio-Botanica's Bio-Chelated® Cold Extraction Process, developed by founder Frank Senior, applies very low or no heat during extraction to preserve the natural constituent ratios of the plant. The result is a Holistically Balanced® extract, a full-spectrum liquid that reflects the root as it was grown. Standard high-heat extraction methods degrade heat-sensitive plant constituents and often fractionate the plant's natural profile.
**Can I request a sample of Bio-Botanica's Dong Quai AF extract?**
Yes. Contact Scott Florentino directly at sflorentino@bio-botanica.com or schedule a time at the link below to discuss your formulation brief, volume requirements, and get a sample out this week.
*The traditional uses described are not validated in multiple, well controlled, clinical scientific studies. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
